Optimising the radiolabelling properties of technetium tricarbonyl and His-tagged proteins
نویسندگان
چکیده
منابع مشابه
Optimising the radiolabelling properties of technetium tricarbonyl and His-tagged proteins
BACKGROUND To date, the majority of protein-based radiopharmaceuticals have been radiolabelled using non-site-specific conjugation methods, with little or no control to ensure retained protein function post-labelling. The incorporation of a hexahistidine sequence (His-tag) in a recombinant protein can be used to site-specifically radiolabel with 99mTc-tricarbonyl ([99mTc(CO)3]+). This chemistry...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2014
ISSN: 2191-219X
DOI: 10.1186/2191-219x-4-14